• SUNITHA S

Abstract: 3-methyl-1-phenyl-5-pyrazolone(MPP) was synthesized by reacting phenylhyrazine and ethylacetoacetate. It was benzoylated using benzoyl chloride to form 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone(BMPP). BMPP was condensed with Sulphanilamide and Sulphamethoxazole to form Schiff bases. The Schiff bases were characterized by infrared spectra, electronic, 1H NMR, 13C NMR, and Mass spectral studies. They were found to be active against the gram negative bacteria Pseudomonas eruginosa and Staphylococcus aureus and the fungi Aspergillus niger and Candida albicans. Cytotoxicity studies indicated that one Schiff base is active against A549 human lung cancer cell lines. Hence these Schiff bases may be used as lead compounds in pharmaceutical industries.

Pyrazolones, Schiff bases, sulpha drugs, antibacterial activity, antifungal activity, cytotoxicity

"Anticancer And Antimicrobial Activities On Schiff Bases Of 4-Benzoyl-3-Methyl-1-Phenyl-5-Pyrazolone Bearing Sulphanilamide And Sulphamethoxazole Moieties", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.106-134, June 2019, Available :http://www.jetir.org/papers/JETIR1906N70.pdf

"Anticancer And Antimicrobial Activities On Schiff Bases Of 4-Benzoyl-3-Methyl-1-Phenyl-5-Pyrazolone Bearing Sulphanilamide And Sulphamethoxazole Moieties", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp106-134, June 2019, Available at : http://www.jetir.org/papers/JETIR1906N70.pdf