• K.Vanaja
• Dr.R.Sivasankar
• V. Uday Kiran
• Dr.K. Chennaiah

Nardostachys jatamansi (family Valerianaceae), an indigenous medicinal plant. It helps to promote physical and mental health augment resistance of the body against disease and has shown potent antioxidant activity. Nicotine is known to induced oxidative stress and depletes antioxidant defense mechanisms in skeletal muscle tissue, on the basis of a antioxidant properties N.Jatamansi have been chosen for the present study. Pathogen free, Male Wistar strain albino rats (3 months as a Young, 18 months as a Old) were used in the present study, rats were divided into 4 groups of six rats in each group and treated as follows :Group I: Normal Control; Group II: Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months );Group III: Nardostachys Jatamansi Extract treated (NJEt) (50mg/kg body weight) via Orogastric tube for a period of 2 months); IV: Nicotine + Nardostachys Jatamansi Extract treated (Nt+NJEt), rats were received the nicotine at a dose as mentioned in Group II through subcutaneous injection and N. Jatamansi Extract as mentioned in Group III via Orogastric tube for a period of 2 months.The animals were sacrificed after 24 hrs after the last treatment session by cervical dislocation. In the present investigation reveals that all ATPase’(Mg2+ and Ca2+ ) activities and Creatine phosphokinase (CPK) were decreased in nicotine treated rats and enhanced was observed in NJEt rats over the control. In the combination treatment (Nt+NJEt) up regulation was observed. This review highlights the importance medicinal properties on skeletal muscle tissue and function and other related disorders, in particular their mechanism of action and therapeutic potential.

Key words: Nicotine, Nardostachys Jatamansi Extract, ATPase (Mg2+ and Ca2+),Creatine phosphokinase(CPK), Skeletal muscle Tissue and Male albino rat

"Defensive role of Nardostachys jatamansi Extract against Nicotine induced Toxicity on Skeletal muscle ATPase (Mg2+ and Ca2+ ATPases) and Creatine phosphokinase in Male Albino rat with reference to Aging.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.803-819, June-2019, Available :http://www.jetir.org/papers/JETIR1906S54.pdf

"Defensive role of Nardostachys jatamansi Extract against Nicotine induced Toxicity on Skeletal muscle ATPase (Mg2+ and Ca2+ ATPases) and Creatine phosphokinase in Male Albino rat with reference to Aging.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp803-819, June-2019, Available at : http://www.jetir.org/papers/JETIR1906S54.pdf