• Fartade A.M
• 2Maniyar M.G

Nifedipine is a calcium channel blocker used to manage angina, high blood pressure. It has poor aqueous solubility and slow dissolution rate lead to a lack of dose proportionality. The aim of this study was to improve the biological performance of the drug by enhancing its solubility. In the present study an attempt has been made to enhance solubility of nifedipine using β-cyclodextrin (β-CD). The complex were prepared by different methods like Physical mixture, Kneading and Solvent evaporation with different ratio.The prepared complexes were characterized using FT-IR and X-ray Diffractometry (XRD). The complex were evaluated for phase solubility, saturation solubility, drug content and powder yield. The Saturation solubility study of optimized formulation was found to be 16.07µg/ml. The Drug content of optimized formulation was found to be 97.3%. The powder yield of optimized formulation was found to be 98.45%. In vitro dissolution study was carried out phosphate buffer solution of pH 6.8, Formulation prepared by kneading method F5 (1:2) and solvent evaporation F8 (1:2) showed 88.51% and 90.23 % drug release respectively.

Nifedipine, β-cyclodextrin, physical mixture, kneading, solvent evaporation, phase solubility, saturation solubility, dissolution rate.

"Crystal engineering technique for the enhancement of nifedipine solubility.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.213-223, June 2019, Available :http://www.jetir.org/papers/JETIR1906U64.pdf

"Crystal engineering technique for the enhancement of nifedipine solubility.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp213-223, June 2019, Available at : http://www.jetir.org/papers/JETIR1906U64.pdf