• Meenakumari
• Dr.K.S.MEENA
• Dr.R.GIRIJA

ABSTRACT: The genera of indigofera (Family Fabaceae) are distributed throughout India and are medicinally useful. Indigofera tinctoria Linn (Fabaceae) has been extensively used in various folklore and traditional medicines, Studies on the plant reveal low toxicity. The plant possesses antitoxic, hemostatic, sedative properties and is useful in the treatment of piles, healing of ulcers, dropsy. The roots stems and leaves are useful for promoting growth of hair, in gastropathy, splenomeghaly, cepholagia, cardiopathy, chronic bronchitis, asthma and ulcers. Extracts of I tincoria (whole plant) contains “indicant”, about 2.5% alkaloids, about 0.5% stimulant deobstruent, antiseptic and astringent . The 3D crystal structure of the protein 11-beta hydroxysteroid dehydrogenase (11-bHSD) was retrieved from protein Data Bank (PDB) and protein binding sites of the compounds were identified. The 2D structure of Indican compounds of glycosides of indane were obtained from the Pubchem database. The present study analysed the molecular docking studies on protein which is responsible for Asthma with the compounds evolved from Indigofera tinactoria Linn. The Docking was done by schrodinger Maestero 11.9 software tool, Indican compounds of glycosides of indane having best binding score than the other compounds. Hence it has been concluded Glycosides of indane can be used as a Anti asthmatic drug.

KEYWORDS: Indigofera tinctoria linn, Indican, 11-beta hydroxysteroid dehydrogenase, Anti asthmatic drug, Maestero 11.9, Glide.

"INSILICO MOLECULAR DOCKING STUDY ON GLYCOSIDES OF INDANE AGAINST ASTHMA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.452-458, June 2019, Available :http://www.jetir.org/papers/JETIR1906V63.pdf

"INSILICO MOLECULAR DOCKING STUDY ON GLYCOSIDES OF INDANE AGAINST ASTHMA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp452-458, June 2019, Available at : http://www.jetir.org/papers/JETIR1906V63.pdf