• N.Deepa
• Rakshana.S
• Rakshana.S

Dental plaque Bio films are responsible for numerous chronic oral infections and cause a severe health burden further it cannot be eliminated, as the bacteria in the Bio films are resistant to the host’s immune defenses and antibiotics. There is a critical need to develop new strategies to control Bio film-based infections. Biofilm formation in Streptococcus mutansis promoted by major virulence factors known as glucosyltransferases (Gtfs), synthesize adhesive extracellular Polysaccharides (EPS). The current study is designed to identify novel molecules that target Gtfs, thereby inhibiting S. mutansbiofilm formation and having the potential to prevent dental caries. Structure-based virtual screening of approximately 150,000 commercially available compounds against the crystal structure of the glucosyltransferase domain of the GtfC protein from S. mutansresulted in the identification of a quinoxaline derivative,2-(methoxyphenyl)-N-(3-{[2-(4 methoxyphenyl)ethyl]imino}-1,4-dihydro-2 quinoxalinylidene)ethanamine, as a potential Gtf inhibitor. The rat model finds that the compound significantly reduced the incidence and severity of smooth and sulcal-surface caries in vivo with a concomitant reduction in the percentage of S. mutants in the animals’ dental plaque (P < 0.05).

Bacteria, Biofilms, compounds, molecules

"MOLECULAR MODELING STUDIES IN VARIOUS DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.560-566, June 2019, Available :http://www.jetir.org/papers/JETIR1906V80.pdf

"MOLECULAR MODELING STUDIES IN VARIOUS DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp560-566, June 2019, Available at : http://www.jetir.org/papers/JETIR1906V80.pdf