• Jadhwar P. S.
• Maniyar M. G.

The objective of the present investigation was to develop a mucoadhesive in-situ gel with reduced nasal mucocilliary clearance in order to improve the bioavailability of the antiasthamatic drug namely montelukast sodium. The in-situ gelation upon contact with nasal mucosa was conferred via the use of the thermo gelling poloxamer 407 whereas mucoadhesion and drug release enhancement were modulated using hydroxy propyl methyl cellulose, methyl cellulose and polyethylene glycol respectively. The results revealed that the mucoadhesive polymer increased the gel viscosity but reduced its sol-gel transition temperatures and the drug release. The inclusion of polyethylene glycol polymer counteracted the effect of mucoadhesive polymer whereby it decreased the gel consistency and increased the sol-gel transition as well as In-vitro drug release. The In-vitro drug release performed through cellophane membrane. The percentage drug content of all the prepared nasal gels formulations were checked and found to be in the range of 89.05-98.30%.

Montelukast sodium, Poloxamer 407.

"Formulation and evaluation of montelukast sodium nasal gel", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.934-944, June 2019, Available :http://www.jetir.org/papers/JETIR1906X20.pdf

"Formulation and evaluation of montelukast sodium nasal gel", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp934-944, June 2019, Available at : http://www.jetir.org/papers/JETIR1906X20.pdf