• Toraskar Sonam Dasharath
• Mr. M.G. Maniyar

Matrix tablet of losartan potassium was prepared by using hibiscus obtained resin and were evaluated as rate controlling matrix materials. Losartan potassium is an class antihypertensive drug and belongs to angiotensin receptor blockers. It is administered orally but has limitation of short half life so selected. Hibiscus resin was studied for solubility, physical characterization and various chemical test were found to be soluble. It showed solubility in methanol, ethanol, lukewarm and cold water while it was insoluble in acetone. The hibiscus resin is prepared by using solvent acetone. It showed ash value 87.25%, pH 2.5±0.22,viscocity 46±0.10 cps. The physiochemical tests having foam test is positive. Losartan potassium tablets were prepared direct compression method by using hibiscus resin. The FTIR study revealed that compatibility of resin and drug. Losartan potassium matrix tablets showed slow and controlled release of losartan potassium over 8 hours. It follows non-fickian type drug kinetic model. Good linear relationships were observed between percent polymer and release rate in each case. Losartan potassium matrix tablet exhibited the optimized formulation of 92% release after 8 hr.

Keywords: Losartan potassium, antihypertensive drug, hibiscus resin.

"Formulation and evaluation of losartan potassium matrix tablet by using natural gum", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.1025-1036, June 2019, Available :http://www.jetir.org/papers/JETIR1906Y69.pdf

"Formulation and evaluation of losartan potassium matrix tablet by using natural gum", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp1025-1036, June 2019, Available at : http://www.jetir.org/papers/JETIR1906Y69.pdf