• Mali Nilesh Dattatray
• Maniyar M. G.

Floating drug delivery system is enable to give prolonged and continuous release of drug to upper part of the gastrointestinal tract and improves the bioavailability of medications that are characterized by a narrow absorption window. A new strategy preferably once a daily is proposed for development of buoyant gastric dosage forms for theophylline. The present design of the delivery system was based on controlled release formulation with floating and swelling features in order to prolong the gastric retention time of the drug.HPMC K4M, carbapol, xanthan gum were used in different concentration in order to get desired controlled release profile over period of 24 hrs. All the formulations were evaluated for drug content and in-vitro drug release profile. It was found that controlled rate of formulation increased with decrease in polymer concentration. The drug release data fitted to Higuchi kinetic model.

Theophylline, HPMC, K4M, carbapol, xanthan.

"Formulation and evaluation of floating drug delivery system ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.107-115, June 2019, Available :http://www.jetir.org/papers/JETIR1906Z15.pdf

"Formulation and evaluation of floating drug delivery system ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp107-115, June 2019, Available at : http://www.jetir.org/papers/JETIR1906Z15.pdf