• Mrs. RESHMA N. MIRAJKAR
• Mrs. KALYANI PRUTHVIRAJ DHAVALE
• Dr. ASHWINI MADGULKAR

Diclofenac is non-steroidal anti-inflammatory analgesic drug (NSAID) with potent cyclooxygenase inhibition activity indicated in the relief of all grades of pain and inflammation associated with a wide range of conditions, including low back pain,arthritic conditions, acute musculo-skeletal disorders and other painful conditions resulting from trauma.The dosage of diclofenac injection is 25 mg per ml, not to exceed 150 mg per day. Diclofenac Sodium is well-absorbed after oral administration with extensive hepatic metabolism. It exhibits a terminal half life of 1–2 hr. Cmax is reached at approximately 4 hours. Diclofenac is associated with serious dose-dependent gastrointestinal, cardiovascular, and renal adverse effects. The gastrointestinal toxicity of Diclofenac through oral administration can be avoided by injecting drug directly at the target site. The in situ forming gel formulation is developed to provide prolong drug release, increase residence time and bioavailability, reduction in frequent dosing and patient compliance.1,2,3,4 The analgesic activity of analgesic or anti-inflammatory agents is evaluated using writhing reflex induced by acetic acid. Writhing reflex is described as stretching, extension of the hind legs and abdominal contractions. Any writhing reflex is regarded as a positive reaction.5,6 The present work was focused on pharmacokinetic evaluation and analgesic activity of the developed sustained release insitu gel forming epidural injection of an analgesic drug Diclofenac sodium for the treatment of low back pain over a 3 days period in order to reduce the frequency of administration and to improve patient compliance.

Pharmacokinetic Studies, Analgesic Activity, In-Situ Forming Gel, Epidural Injection

"Evaluation of Pharmacokinetic Studies and Analgesic Activity of Sustained Release Epidural Injection of Analgesic Drug on Wistar Rat", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.518-525, June 2019, Available :http://www.jetir.org/papers/JETIR1907217.pdf

"Evaluation of Pharmacokinetic Studies and Analgesic Activity of Sustained Release Epidural Injection of Analgesic Drug on Wistar Rat", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp518-525, June 2019, Available at : http://www.jetir.org/papers/JETIR1907217.pdf