• Chavan Amit N.
• Dr. Chemate Satyam Z.

The aim of current investigation was to formulate an effective drug delivery system for patients suffering from cardiovascular problems such as early morning Prinzmetal’s angina. To achieve this goal, pulsatile drug delivery was selected because it delivers the drug at right time and at right situation. PTC and PTN drug was taken for getting relief from cardiac problem. The core tablet was prepared using superdisintegrant for instant release. Direct compression technique was used for preparation of core tablet. Core tablet were further compression with HPMC E15 and E50 for lag time. The compressed tablets were evaluated for acceptable physical properties, in-vitro drug release and stability study. The result indicated that compressed coated F6 formulation shows rapid and complete drug release of PTC and PTN after 6 hours lag time which is suitable for both drug to achieve time control release, based on chronopharmacutical approach for the treatment of angina.

HPMC E15, HPMC E 50, Pulsatile drug delivery, Prinzmetal’s angina

"FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM USING NOVEL ANTI-HYPERTENSIVES FOR THE CHRONOTHERAPY OF ANGINA.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.890-906, June 2019, Available :http://www.jetir.org/papers/JETIR1907582.pdf

"FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM USING NOVEL ANTI-HYPERTENSIVES FOR THE CHRONOTHERAPY OF ANGINA.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp890-906, June 2019, Available at : http://www.jetir.org/papers/JETIR1907582.pdf