• M. Rahil Bhura
• Dr. Akruti Khodakiya
• Dr. Samir K. Shah
• Jyoti Shibag

The Intension of this research was to discover the passive and electrically triggered transdermal transport of Tapentadol hydrochloride (TPH) by iontophoresis. For better bioavailability, better patient compliance, enhanced delivery of TPH, an iontophoretic drug delivery system of a thermosensitive TPH gel and Pluronic lecithin organogel (PLO) was formulated using Lutrol F-127 and Pluronic Lecithin Gel. The study was carried out by the help of silversilver chloride electrodes throgh hairless pig skin. The effects of polymer concentration, pH, electrode design, and pulse rate on the TPH permeation were explored. The relationship between temperature, viscosity, and conductance of TPH was correlated using conductometry. Iontophoretic transportation of TPH was found to be increasing with a decreasing in the pH of the medium and an increase in the surface area of the electrode. Anodal pulsed iontophoresis with disc electrode significantly increased the TPH skin permeation as compared with the passive controls.

Tapentadol Hydrochloride, Thermosensitive Gels, PLO, Conductance, Viscosity, Permeation, Pulsed current.

"Comparative Studies of Electrically assisted transdermal transport of Thermosensitive gel and Pluronic lecithin organogel (PLO) containing Tapentadol hydrochloride (TPH) by iontophoresis.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.702-719, June 2019, Available :http://www.jetir.org/papers/JETIR1907856.pdf

"Comparative Studies of Electrically assisted transdermal transport of Thermosensitive gel and Pluronic lecithin organogel (PLO) containing Tapentadol hydrochloride (TPH) by iontophoresis.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp702-719, June 2019, Available at : http://www.jetir.org/papers/JETIR1907856.pdf