• A. K. Nangare
• G.K.Nawathe
• P.R.Varade

This study includes development of RP-HPLC method for estimation of Irbesartan. The developed method was validated as per ICH guidelines in terms of specificity, accuracy, linearity, LOD, LOQ, ruggedness and robustness. The inter-day and intra-day precision results were good enough to indicate that the proposed method was precise and reproducible. The assay experiment showed that the contents of Irbesartan estimated in the tablet dosage were free from interference of excipients, which indicate that developed method was specific. Recovery of standard added drugs was found to be 97.2-99.9% for Irbesartan indicating that the proposed method was accurate. A good linear relationship was observed for standard drug of Irbesartan and tablet form of Irbesartan in the concentration ranges of 60 – 100 µ/ml . The correlation coefficient for Irbesartan was found to be 0.998 µ/ml. After performing analysis by different analyst; it was found that the RP-HPLC method for the determination of Irbesartan was found to be rugged. % RSD for robustness was well within the limits ensuring that the proposed method was robust. The LOD was 0.710 µ/ml for standard drug of Irbesartan. For standard drug of Irbesartan the LOQ were found to be 0.116 µ/ml This demonstrated that the developed RP-HPLC method was simple, linear, precise, accurate, robust and rugged, could be conveniently adopted for the routine quality control analysis of Irbesartan from it’s pharmaceutical dosage form and bulk drug.

Irbesartan,RP-HPLC

"Method Development and Validation of Irbesartan by RP-HPLC Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.492-499, June 2019, Available :http://www.jetir.org/papers/JETIR1907C33.pdf

"Method Development and Validation of Irbesartan by RP-HPLC Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp492-499, June 2019, Available at : http://www.jetir.org/papers/JETIR1907C33.pdf