• Patel Shivani P.
• Vyas Tulsi H.
• Detholia Krunal K.

Design of Experiments (DoE) have been widely used to understand the effects of multidimensional and interactions of input factors on the output responses of pharmaceutical products and analytical methods. It is always important before beginning experimentation to determine the objective of an experiment, and this is no different with DoE. Identifying objectives helps focus a team on its specific aims (scientific understanding of the task/problem in hand) over a period of time. It has been suggested that DoE can offer returns that are four to eight times greater than the cost of running the experiments in a fraction of the time that it would take to run one-factor-at-a-time experiments .This review shows about the principles and applications of the most common screening designs, such as two-level full factorial, fractionate factorial, and Plackett-Burman designs; and optimization designs, such as three-level full factorial, central composite designs (CCD), and Box-Behnken designs. DoE studies in support of QbD are often a delicate balance between delivering defined, high-quality products and meeting predetermined time, labor, and financial constraints. Statistical terms and procedure were found in nearly all of the research articles published. Thus, pharmacy education should aim to provide current and future pharmacists with an understanding of the common statistical terms and procedures identified to facilitate the appropriate appraisal and consequential utilization of information.

Design of Experiments (DoE), Statistics, Biostatistics, Experimental designs., Applications of Statistics and DoE

"Biostatistics: A Revolutionary Approach For Optimization Of New Drug Formulation And Development", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 9, page no.588-603, September 2019, Available :http://www.jetir.org/papers/JETIR1907D83.pdf

"Biostatistics: A Revolutionary Approach For Optimization Of New Drug Formulation And Development", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 9, page no. pp588-603, September 2019, Available at : http://www.jetir.org/papers/JETIR1907D83.pdf