• Mrs Manasi Khadanga
• Mr. Sujit ku. Martha
• Mrs Pratit Kanchan Sahu
• Mr. Durga Madhav Dash

BRHAM KAMAL (Epiphyllum oxypetalum): WOUND HEALING ACTIVITY STUDY Brahma Kamal and few other related species of the thistle tribe of plants are native to the Himalayas. Their flowers bloom during mid-monsoon months amongst the rocks and grasses. These extremely rare plants are not only famous for their beautiful flowers, but also for their significant importance in traditional medicine. The entire plant of Brahma Kamal can be employed as a remedy for a large number of human diseases. Due to its bitter nature, it is an excellent liver tonic and a great appetiser. Soup made from this plant helps soothe liver inflammations and also increases blood volume in the body. Plant juice is useful to treat urinary tract disorders. It clears recurrent urinary tract infections, and can be used as an excellent medicine for sexually transmitted diseases. Wound contraction, which contributes to wound closure, is expressed as a reduction in percentage of the original wound size is studied starting from the day of operation until the day of complete Epithelialization and evaluated to calculate the degree of wound healing. Wound tissues are analyzed for hydroxyproline content; the collagen composed of amino acid (hydroxyproline) is the major component of extracellular tissue, which gives strength and support. Breakdown of collagen liberates free hydroxyproline and its peptides. Measurement of hydroxyproline, hence, can be used as a biochemical marker for tissue collagen and an index for collagen turnover. In the present study ethanolic extract were prepared from leaves of Epiphyllum oxypetalum and its wound healing activity was studied by using established models in rats. To study the wound healing activity of ethanolic extract, the excision wound model is selected because the technique is simple to be used for routine screening of wound healing activity. Key words: Epiphyllum oxypetalum, hydroxyproline, Epithelialization, wound healing, Brahma Kamal Author detail: 1) Main author :Mrs Manasi Khadanga, pharma cology dept.Jeypore College Of Pharmacy.rondapali .jeypore. 2) Co-author : Mr. Sujit ku. Martha, pharma cology dept.Jeypore College Of Pharmacy.rondapali .jeypore. 3) Co-author : Mrs Pratit Kanchan Sahu. , pharma cology dept.Jeypore College Of Pharmacy.rondapali .jeypore. 4) Co-author : Mr. Durga Madhav Dash .Zoology dept. Biju Pattnaik College Kundura.Jeypore.

Epiphyllum oxypetalum, hydroxyproline, Epithelialization, wound healing, Brahma Kamal

"BRHAM KAMAL (Epiphyllum oxypetalum): WOUND HEALING ACTIVITY STUDY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.306-312, June 2019, Available :http://www.jetir.org/papers/JETIR1907I41.pdf

"BRHAM KAMAL (Epiphyllum oxypetalum): WOUND HEALING ACTIVITY STUDY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp306-312, June 2019, Available at : http://www.jetir.org/papers/JETIR1907I41.pdf