• Pallavi Gupta
• Sharad Kumar Mathur
• Mandeep Manohar H Madia

Context: Direct laryngoscopy and endotracheal intubation following induction of anesthesia is almost always associated with hemodynamic stress response due to reflex sympathoadrenal discharge. Aim & Objectives: Aim of our study was to compare the efficacy of lignocaine and verapamil in attenuating the hemodynamic response to laryngoscopy and intubation. The present prospective randomized study was carried out in a tertiary care teaching hospital. A total of 60 American Society of Anesthesiologist physical status I and II patients posted for elective surgery under general anesthesia were enrolled in the study. Patients were randomly divided into two groups, group L (lignocaine group) and group V (verapamil group) with 30 patients in each group. Materials and Methods: Group L received 1.5 mg/kg of lignocaine intravenous (IV) and group V received.1 mg/kg of verapamil IV. propofol was given until verbal response disappeared, and intubation was facilitated with vecuronium. Anesthesia was maintained with oxygen: Nitrous oxide, isoflurane, and vecuronium. Hemodynamic parameters were recorded during the before intubation, immediate after intubation, 1 min,2min, 3 min, 5 min after intubation. Conclusion: Lignocaine attenuates the hemodynamic stress response to laryngoscopy and intubation more effectively compared with verapamil without any deleterious effects.

Key words: Hemodynamic stress response, intubation, laryngoscopy, lignocaine, verapamil

"A Comparison of efficacy of I.V.Lignocaine and I.V.Verapamil for attenuation of stress response to laryngoscopy and Tracheal intubation", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.306-311, June 2019, Available :http://www.jetir.org/papers/JETIR1907K46.pdf

"A Comparison of efficacy of I.V.Lignocaine and I.V.Verapamil for attenuation of stress response to laryngoscopy and Tracheal intubation", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp306-311, June 2019, Available at : http://www.jetir.org/papers/JETIR1907K46.pdf