• MUDITA MISHRA
• SANTOSH KUMAR VERMA

Parkinson disease is one of the major movement related disoreder in elderly patients. The symptoms are rigidity, tremor, bradykinesiafollowed by akinesia and postural abnormality. The current scenario of synthetic drug treatment gives symptomatic relief and the patient’s quality of life gets increased. Amphetamine and methamphetamine are the metabolite of Selegeline (MAO B inhibitor) causes side effectlike Anxiety and Insomnia and number of side effect like hallucinations, Diarrhoea, postural hypotension. The drug Madhucaindiaca has property to inhibit (neuronal NOS) nitric oxidasesynthase inhibitor, one of the major enzyme to produce oxidative stress by the mechanism of apoptosis, it also suppress MDA level, a marker of oxidative stress, while Psiduimguajava have polyphenolic compounds that has important role to suppress oxidative stress, that has key role in the Pathogenesis of Parkinson Disease. This review suggests the opinion of different authors on ethanopharmacology of Psiduim guajava and Madhuca indica. It has protective role in pathogenesis of Parkinson’s Disease.

PD- Parkinson Disease, Nnos-Neuronal nitric Oxide Synthase, MAO- Mono Amino Oxidase, MDA –Malonaldialehyde

"Ethnopharmacological aspects of Psiduim guajava And Madhuca Indica", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.658-668, June 2019, Available :http://www.jetir.org/papers/JETIR1907O80.pdf

"Ethnopharmacological aspects of Psiduim guajava And Madhuca Indica", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp658-668, June 2019, Available at : http://www.jetir.org/papers/JETIR1907O80.pdf