• V.M.K.Naveen
• Veeraswami B
• Srinivasarao G

A validated stability-indicating UPLC method for Alpha Lipoic Acid and Enzogenol was developed by separating its degradation products on a RP18 (150x4.6mm, 2.1µm) Waters X-Terra column using water and acetonitrile in simple Isocratic at a flow rate 1.0 ml/min. The column effluents were monitored by a photodiode array detector set at 228 nm. The method was validated in terms of specificity, linearity, accuracy, precision, detection limit, quantification limit and robustness. Forced degradation of Alpha Lipoic Acid and Enzogenol was carried out under acidic, basic, peroxide, reduction, thermal, photo and hydrolysis conditions. The proposed method is validated as per ICH Q2 (R1) guidelines.

STABILITY INDICATING ASSAY OF ALPHA LIPOIC ACID AND ENZOGENOL BY UPLC AND ITS DEGRADATION

"DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING ASSAY OF ALPHA LIPOIC ACID AND ENZOGENOL BY UPLC AND ITS DEGRADATION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.651-657, June 2019, Available :http://www.jetir.org/papers/JETIR1907Q01.pdf

"DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING ASSAY OF ALPHA LIPOIC ACID AND ENZOGENOL BY UPLC AND ITS DEGRADATION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp651-657, June 2019, Available at : http://www.jetir.org/papers/JETIR1907Q01.pdf