• Dr.Malleti.Sreedhar
• Dr..A.Bhujangarao

This paper deals with the introduction about renal system of human body and concentrated upon effects of renal system under non clearance of creatinine .It is also discussed in this paper that various methods used for the measurement of clearance. This paper can give clear idea about glomerular filtration rate an creatinine clearance. Further discussed about analytical methodologies used in measuring the same such as End point and kinetic reaction methods. The chief functions of the kidneys are to filter the blood, which regulates the concentration of water and sodium, to reabsorb water, glucose and amino acids, and to excrete the waste as urine. The typical adult produces 1 – 2 liters of urine per day dependent upon such factors as hydration and activity levels, environmental factors, weight, and the individual’s state of health. Thin tubes, called ureters, transport small amounts of urine from the kidneys to the bladder about every 10 – 15 seconds. A healthy bladder can hold up to 2 cups of urine comfortably for two to five hours [1].

Creatinine, glomerular filtration rate (GFR), End point and kinetic reaction methods

"Measurement and analysis of creatinine, creatinine clearance and its effect on kidneys using interference filters", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.986-989, June 2019, Available :http://www.jetir.org/papers/JETIR1907Q47.pdf

"Measurement and analysis of creatinine, creatinine clearance and its effect on kidneys using interference filters", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp986-989, June 2019, Available at : http://www.jetir.org/papers/JETIR1907Q47.pdf