• Balasubramaniam S
• Latha V
• Ambikapathy V

Melia azedarach L., a deciduous tree of moderate size, grown throughout warm countries possesses various uses in our life. The extract of leaves in different solvent systems (aqueous and methanol) when applied to mosquito repellent. Melia azedarach L., a close relative of neem from the family Meliaceae which occurs in India and other tropical and subtropical countries. It has been reported to possess antimicrobial, insecticidal and nematicidal properties. The study of medicinal properties of Melia azedarach is used as home medicine in India and it may contains more bioactive compounds to treat various diseases such as Diabetes, Skin diseases, etc., The effect of different concentration of neem leaf extract against four bacterial and four fungal pathogens (bacterial pathogens: E.coli, K.pneumoniae, Entrococcus sp, and S. aureus. fungal pathogens: Aspergillus niger, A.terreus, Penicillium sp, and Fusarium sp). The aqueous and methanol extract of Melia azedarach exhibited broad spectral activity against both bacterial and fungal pathogens. The antibacterial properties of Melia azedarach leaf with different concentration of 25, 50, 75 and 100µl and two solvents like aqueous and methanol was individually detected. The maximum antibacterial activity of M. azedarach with 100µl leaf extract concentration was excellent performance then the lower concentration whereas the minimum activity at 25µl concentration was recorded with respective plant leaf extract. The effect of antifungal activity was tested. The higher concentration 100µl of Melia azedarach leaf extract showed extraordinary inhibition recorded against clinical fungi. Whereas minimum concentration of 25µl has moderate activity was observed. Therefore the crude extracts of Mountain neem exhibited antibacterial and antifungal activities. The active phytocompounds isolation and identification is necessary to find out the pharmacological important compounds to treat various diseases.

Melia azedarach, microbes, antimicrobial activity

"DETERMINATION OF ANTIMICROBIAL ACTIVITY OF Melia azedarach L. AGAINST CLINICAL MICROBES ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.249-254, June 2019, Available :http://www.jetir.org/papers/JETIR1907Q80.pdf

"DETERMINATION OF ANTIMICROBIAL ACTIVITY OF Melia azedarach L. AGAINST CLINICAL MICROBES ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp249-254, June 2019, Available at : http://www.jetir.org/papers/JETIR1907Q80.pdf