• Smita Prakash Kakad
• Sanjay Jayprakash Kshirsagar
• Yash Bharti

Central Nervous System (CNS) disorder like HAND, multiple sclerosis, alzheimer’s disease speak to a developing general medical problem because of the expanded future and aging population. The treatment of such disease is quite intricate and require the delivery of therapeutics to the brain in effective concentration to exhibit a pharmacological response. Effectiveness related issues emerge because of failure of macromolecule to cross the blood brain barrier (BBB) to elicit their significant delivery to the brain tissue and cerebrospinal fluid (CSF).The nose-to-brain delivery has developed effective route to bypass the BBB and deliver the medications to the brain. There are various nanotechnology drug delivery system approaches available such as nanoemulsion, nanosuspension, lipid nanoparticles, liposomal nanoparticle, magnetic nanoparticle delivery, macrophages carrier etc. Development of brain drug delivery is very tough task because of the presence of various physiological barriers called BBB and presence of efflux transporters puts restriction on the delivery of drug to the central nervous system. Since from last decade, intranasal route attracted wide attention of researcher as effective, noninvasive, reliable and safer route to achieve effective level of drug with faster rate in brain and CSF via olfactory and trigeminal pathway by passing blood brain barrier.

Nose to brain, Blood brain barrier, Brain targeting, Nasal drug delivery, Delivery pathway.

"CURRENT NANO DRUG DELIVERY STRATEGIES AVAILABLE FOR NOSE TO BRAIN DRUG TARGETING", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.778-786, June-2019, Available :http://www.jetir.org/papers/JETIR1907T84.pdf

"CURRENT NANO DRUG DELIVERY STRATEGIES AVAILABLE FOR NOSE TO BRAIN DRUG TARGETING", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp778-786, June-2019, Available at : http://www.jetir.org/papers/JETIR1907T84.pdf