• Ratna Kumari Padamati
• Hemalatha Nakka
• Bhavani Bodedda

DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE IN SITU ORAL FLOATING GEL OF ANTIPROTOZOVAL DRUG METRONIDAZOLE Ratna kumari Padamati1, Hemalatha Nakka2, Bhavani Boddeda & Priyanka Bonepalli. 1. Assistant professor, department of pharmacy practice, Koringa College of Pharmacy, korangi- 533461. East Godavari, Andhra Pradesh. e-mail ID: ratnakumari022@gmail.com. Mobile: 91-7702471130 2. Assistant professor, department of pharmacy practice, Koringa College of Pharmacy, korangi- 533461. East Godavari, Andhra Pradesh. e-mail ID: hemalathar.mpharm@gmail.com. Mobile: 91-8919162631 ABSTRACT Object: The objective of present study is to prepare and evaluate floatable in situ gastro retentive gel of Metronidazole drug . Method: Metronidazole floating gel system is prepared by dissolving viscosity forming agent HPMC in distilled water to which calcium carbonate and metronidazole was added then dissolved sodium alginate in distilled water then add to the HPMC solution and volume is adjusted to 100ml then evaluate the prepared formulae for Drug content, pH measurement, gelling capacity, floating ability, in vitro drug release behavior. Results: The formulation variable such as viscosity enhancing polymer i.e sodium alginate affects the formulation viscosity, floating behavior, in vitro drug release, gelling capacity. Conclusion: The prepared gastric specific in situ gel of metronidazole which is used in peptic ulcer diseases caused by H.pylori was prepared by HPMC and sodium alginate as release retardant it was found that in increase concentration of polymer decrease drug release .

Keywords: in situ floating gel, Gastro retentive, Metronidazole, HPMC, Sodium alginate.

"DEVELOPMENT AND EVALUTION OF GASTRO RETENTIVE IN SITU ORAL FLOATING GEL OF ANTIPROTOZOVAL DRUG METRONIDAZOLE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.891-901, June 2019, Available :http://www.jetir.org/papers/JETIR1908289.pdf

"DEVELOPMENT AND EVALUTION OF GASTRO RETENTIVE IN SITU ORAL FLOATING GEL OF ANTIPROTOZOVAL DRUG METRONIDAZOLE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp891-901, June 2019, Available at : http://www.jetir.org/papers/JETIR1908289.pdf