• M.C.Harish
• R.Pradeepraj
• D.Jayarajan

Emergence of multi drug resistant bacterial strains is a growing global concern and in particular strains of Pseudomonas aeruginosa acquires various significant virulent characters frequently and they are always versatile than other groups of bacteria in acquiring drug resistant mechanism. Cyanogenesis, Pyocyanin and extended spectrum of beta lactamase (ESBL) production makes this bacteria more virulent than other pathogens in the current scenario. Hence the study is sought for the detection of cyanogenesis and ESBL production among the clinically recovered isolates. The results exposed that among the isolated Pseudomonas aeruginosa strains 17.64% produced high and 35.2% produced low and 47% with no cyanide production, 58.8% of the strains produce pyocyanin a phenazine compound, ranging from (3.02 - 9.38µg/mL) Further its antibacterial activity also were estimated during the investigation. The pigment produced significant antibacterial activity against other clinical pathogen. 67.7% were ESBL producers which indicates that the organism should be given more attention during treatment and other clinical studies. The ESBL confers more drug resistant characters to the bacterium. The result also concluded that treatment for Pseudomonas aeruginosa infections should include cyanide detoxifying agent and based on that, drug should be chosen for effective treatment

HCN production, ESBL, MAR index ,Pseudomonas aeruginosa, Pyocyanin

"EFFICACY OF PYOCYANIN, EXTENDED-SPECTRUM BETA-LACTAMASE AND HCN PRODUCTION IN PSEUDOMONAS AERUGINOSA IN CLINICAL SETTINGS – AN EMERGING THREAT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.494-508, June 2019, Available :http://www.jetir.org/papers/JETIR1908376.pdf

"EFFICACY OF PYOCYANIN, EXTENDED-SPECTRUM BETA-LACTAMASE AND HCN PRODUCTION IN PSEUDOMONAS AERUGINOSA IN CLINICAL SETTINGS – AN EMERGING THREAT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp494-508, June 2019, Available at : http://www.jetir.org/papers/JETIR1908376.pdf