• Gajanan Shivaji Patil
• Dr.N.S.Naikwade

Depression is referred as an affective disorder which is described by alteration in mood, absence of interest in the surroundings, psychomotor retardation and melancholia. The aim and objectives of present research work is to assess the antidepressant activity and compare the effectiveness of marketed Ayurvedic formulations in mice by using Despair Swim Test and Tail Suspension Test and also estimate the concentration of Nor adrenaline from mouse brain by using Photoflurimeter. The experimental design for present work was the animals were divided into 08 groups and each group contains 06 mice and by using per oral route for 14 days of treatments the Immobility Period was noted on First, Seventh and Fourteenth day. Forced Swim Test: Group I Control it contains distilled water having dose 10 ml / kg , Group II Standard (Imipramine), dose -15 mg / kg, Group III Formulation A having dose 1.3 ml / kg, Group IV Formulation B dose -1.56 ml / kg. Tail Suspension Test: Group V Control it contains distilled water having dose 10 ml / kg , Group VI Standard (Imipramine), dose -15 mg / kg, Group VII Formulation A having dose 1.3 ml / kg, Group VIII Formulation B dose -1.56 ml / kg. The conclusion of present studies are Formulation A and B possess significant antidepressant activity and Formulation B is highly effective as compared to Formulation A as observed in two models which are employed in this study. However, the precise mechanism of action by which the plants in the formulations shows the antidepressant like effect are not completely studied. So the further additional studies are necessary to isolate the exact active chemical constituents which are responsible for antidepressant action.

Depression, Antidepressant drugs, Forced Swim Test, Tail Suspension Test.

"EVALUATION AND COMPARISON OF ANTIDEPRESSANT ACTIVITY OF MARKETED AYURVEDIC FORMULATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.735-747, June 2019, Available :http://www.jetir.org/papers/JETIR1908577.pdf

"EVALUATION AND COMPARISON OF ANTIDEPRESSANT ACTIVITY OF MARKETED AYURVEDIC FORMULATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp735-747, June 2019, Available at : http://www.jetir.org/papers/JETIR1908577.pdf