• KOKKULA PAVAN KUMAR
• BONDA RAMBABU

Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with adverse renal effects caused by the reduction in synthesis of renal prostaglandins in sensitive persons or animal species, and potentially during long-term use in non-sensitive persons if resistance to side effects decreases with age. The effects of Aceclofenac sodium on the kidneys were studied during 4 1/2 hours in eight patients with normal renal function. Urinary output decreased within 10 min after the injection, and maximally by 80%. The renal plasma flow and the glomerular filtration rate initially diminished significantly, by 35%, but began to increase after only 2 hours. The dominant and persistent effect was a reduction of free water clearance, with maximum fall from 5.9 to 0.08ml/min after 2 1/2 hours. Aim: The aim of this study was to evaluate the effects of Aceclofenac-induced acute nephrotoxicity using biochemical parameters in rats.

Aceclofenac, Impaired renal function, Nephrotoxicity, Uremia

"ACECLOFENAC-INDUCED PHYSICOCHEMICAL ALTERATIONS IN TOXICITY AMONG MALE ALBINO RATS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.91-95, June 2019, Available :http://www.jetir.org/papers/JETIR1908627.pdf

"ACECLOFENAC-INDUCED PHYSICOCHEMICAL ALTERATIONS IN TOXICITY AMONG MALE ALBINO RATS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp91-95, June 2019, Available at : http://www.jetir.org/papers/JETIR1908627.pdf