• POPIN KUMAR
• DR. TULSI BISHT

Oral drug delivery is the largest and the oldest segment of the total drug delivery market. It is the fastest growing and most preferred route for drug administration. The tablet coating is perhaps one of the oldest pharmaceutical processes still in existence. It offers many benefits namely – improving the analgesic quality of the dosage form, masking unpleasant order or taste, easing ingestion, improving product stability and modified the release characteristic of the drug. A Film coating is a barrier applied to oral medication that controls or masking unpleasant order or taste of the drug & as a rate controlling membrane for different formulation in digestive system where it is absorbed. . In the present investigation involves Design and Evaluation of Film coated tablet with using HPMC-E15 PVP K-30, Pregelatinized Starch and Sodium starch Glycolate by wet granulation method. Tablet was prepared using sodium starch Glycolate, Pregelatinized Starch, povidone k 30, maize starch, magnesium stearate and talc. In the Film coating process, coating polymer like HPMC-E15, plasticizer like PEG 6000, antitacking agent like talc and solvent like Isopropyl alcohol, Dichloromethane were important. The HPMC-E15 was used in the formulation ATT (139)201, 202, 203, and 204 respectively for coating polymer. The forth trial was performed by decreasing amount of Starch as binder in binder preparation with PVP K-30 for improving binding property and using water & IPA in ratio 1:1 for coating Solution. The in post compression parameter of coated tablet like hardness, thickness, average weight were found to be 116±12 N, 5.40±0.05 mm, and 634±3.5 mg respectively. In disintegration test, coated tablet disintegrate in neutral media in 4 min 34sec. The ATT (139)204 formulation showed cumulative % drug release 101.43±0.25. The superdisintegrant sodium starch glycolate was used in all formulation ATT (139)201, 202, 203, 204. In the experimental level, we have changed some parameters like concentration of binder in different formulation, composition of coating materials etc. Stability evaluations also confirmed that Formula ATT (139)204 was the best formulation. Thus Formula ATT (139)204 fulfills all the criteria for an optimized formulation.

"FORMULATION, DEVELOPMENT & EVALUATION OF COMBINATION OF TRAMADOL & ACETAMINOPHEN FILM COATED TABLETS BY WET GRANULATION METHOD USING PVP K-30, MAIZE STARCH AS BINDER & HPMC E 15 AS FILM COATING POLYMER.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.198-218, June 2019, Available :http://www.jetir.org/papers/JETIR1908644.pdf

"FORMULATION, DEVELOPMENT & EVALUATION OF COMBINATION OF TRAMADOL & ACETAMINOPHEN FILM COATED TABLETS BY WET GRANULATION METHOD USING PVP K-30, MAIZE STARCH AS BINDER & HPMC E 15 AS FILM COATING POLYMER.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp198-218, June 2019, Available at : http://www.jetir.org/papers/JETIR1908644.pdf