• Dr. K.Narasimha Varma

Diabetes mellitus is potentially affecting directly or indirectly, various functions of the reproductive system. Aloe vera extract is an effective agent in ameliorating the oxidative stress found in diabetes. Vitamin C, or ascorbic acid, is an important antioxidant substance in biological systems. The purpose of this study was to investigate the synergistic effects of Aloe vera extract and Vit.C on spermatogenic and steroidogenic activities of diabetic induced male rats. Aloe vera leaf gel extract, Vit.C and a mixture of both administered to three groups of male wistar strain albino rats for 30 days. Then the activity levels of 3-β HSD, 17-β HSD and Androgen dependent enzymes and the levels of hormones like Testosterone, FSH and LH were analysed. The diabetic rats treated with Aloe vera leaf gel extract in combination with Vit.c exhibited increased activity levels of 3-β HSD, 17-β HSD and androgen dependent enzyme activities when compared to other groups. Analysis of testosterone, FSH and LH levels has shown that the levels these hormones increased in the group that treated with mixture of both Aloe vera and Vit.c. According to the results of this study, the mixture of Aloe vera and Vit.C has good potential in increasing the steroidogenesis and spermatogenesis in diabetic induced male rats.

Diabetes, Steroidogenesis, Spermatogenesis, Aloe vera, Vitamin C, Testosterone, FSH, LH, 3-β HSD, 17-β HSD.

"Synergistic effect of Aloe vera and Vitamin C in regulating the steroidogenic and spermatogenic abnormalities of streptozotocin induced male diabetic rats.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.89-95, June 2019, Available :http://www.jetir.org/papers/JETIR1908B13.pdf

"Synergistic effect of Aloe vera and Vitamin C in regulating the steroidogenic and spermatogenic abnormalities of streptozotocin induced male diabetic rats.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp89-95, June 2019, Available at : http://www.jetir.org/papers/JETIR1908B13.pdf