UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1908B38


Registration ID:
225790

Page Number

271-284

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Title

Formulation and evaluation of Lamivudine ethosomes for the treatment of AIDS disease.

Abstract

The main objective of the present work was to develop transdermal delivery of lamivudine for the treatment of AIDS, from ethosomes. Ethosome become an area of research interest in formulation because of it’s enhance skin permeation and improve entrapment efficiency. Lamivudine loaded ethosomal carriers were prepared, optimized and characterized for microscopy, vesicular size, entrapment efficiency, stability and in-vitro release study. The entrapment efficiency of optimized formulation containing lamivudine ethanome F7 was found to be highest (74.12%) while F4 formulation showed least entrapment efficiency (58.81 %). Transmission Electron Microscope (TEM) indicated that ethosome have a discrete spherical structure without aggregation. It has been observed the formulation containing phospholipid (3 gm) with 40 ml ethanol with Tween 80 and SLS has maximum entrapment efficiency. Percentage drug release of ethosomal F7 and F8 containing Lamivudine drug was observed to be 27.33 % and 26.43% (at 30 min.) and 78.49 % & 72.92% (at 120 min.) respectively. It was observed that ethosome formulation F7 showed maximum drug release as compared to other formulation.

Key Words

Lamivudine, ethosomal, entrapment efficiency, Transmission Electron Microscope.

Cite This Article

"Formulation and evaluation of Lamivudine ethosomes for the treatment of AIDS disease. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.271-284, June-2019, Available :http://www.jetir.org/papers/JETIR1908B38.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Formulation and evaluation of Lamivudine ethosomes for the treatment of AIDS disease. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp271-284, June-2019, Available at : http://www.jetir.org/papers/JETIR1908B38.pdf

Publication Details

Published Paper ID: JETIR1908B38
Registration ID: 225790
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier):
Page No: 271-284
Country: bhopal, M.P, India .
Area: Pharmacy
ISSN Number: 2349-5162


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