• Ravikant gupta
• Anjana bhardwaj
• Dr. Alok Pal Jain

The main objective of the present work was to develop transdermal delivery of lamivudine for the treatment of AIDS, from ethosomes. Ethosome become an area of research interest in formulation because of it’s enhance skin permeation and improve entrapment efficiency. Lamivudine loaded ethosomal carriers were prepared, optimized and characterized for microscopy, vesicular size, entrapment efficiency, stability and in-vitro release study. The entrapment efficiency of optimized formulation containing lamivudine ethanome F7 was found to be highest (74.12%) while F4 formulation showed least entrapment efficiency (58.81 %). Transmission Electron Microscope (TEM) indicated that ethosome have a discrete spherical structure without aggregation. It has been observed the formulation containing phospholipid (3 gm) with 40 ml ethanol with Tween 80 and SLS has maximum entrapment efficiency. Percentage drug release of ethosomal F7 and F8 containing Lamivudine drug was observed to be 27.33 % and 26.43% (at 30 min.) and 78.49 % & 72.92% (at 120 min.) respectively. It was observed that ethosome formulation F7 showed maximum drug release as compared to other formulation.

Lamivudine, ethosomal, entrapment efficiency, Transmission Electron Microscope.

"Formulation and evaluation of Lamivudine ethosomes for the treatment of AIDS disease. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.271-284, June-2019, Available :http://www.jetir.org/papers/JETIR1908B38.pdf

"Formulation and evaluation of Lamivudine ethosomes for the treatment of AIDS disease. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp271-284, June-2019, Available at : http://www.jetir.org/papers/JETIR1908B38.pdf