UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1908B58


Registration ID:
230637

Page Number

451-458

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Title

Formulation of Taste Masked Orodispersible Tablets of Tramadol Hydrochloride and Comparative In Vitro Dissolution Profile With Market Product

Abstract

In this study a taste masked orodispersible tablets of Tramadol Hydrochloride were prepared and evaluated for comparative in vitro dissolution profile with commercially available market product. The bioequivalence of Test and Reference product of Tramadol Hydrochloride tablets using in vitro multipoint dissolution profile study by UV-Visible spectrophotometry were performed. Dissolution medium were purified water & three different buffer solutions of different pH like pH 1.2 (hydrochloric acid solution), pH 4.5 (acetate buffer solution), and pH 6.8 (phosphate buffer solution). The Test and Reference tablets were also evaluated to general quality test of dispersible tablets like weight variation, hardness, friability, disintegration time or dispersion time water absorption ratio, wetting time and assay. Both Test & Reference product were complied with the official specification for uniformity of weight, friability and disintegration time and Assay. The dissolution profiles showed there are no significant change drug release of Test and Reference product of Tramadol Hydrochloride Tablets. The tablets were further analysed for similarity between the dissolution profile of Test and Reference product through determination of difference factor (f1), similarity factor (f2) by calculating the dissolution results of both Test and Reference product at multi time point after 05, 10, 15, 30, 45 minutes. These results similarity factor shows that the both Test and Reference product tablets in this study were bioequivalent.

Key Words

Dissolution profile, Similarity factor (f2), Tramadol Hydrochloride

Cite This Article

"Formulation of Taste Masked Orodispersible Tablets of Tramadol Hydrochloride and Comparative In Vitro Dissolution Profile With Market Product", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.451-458, June-2019, Available :http://www.jetir.org/papers/JETIR1908B58.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Formulation of Taste Masked Orodispersible Tablets of Tramadol Hydrochloride and Comparative In Vitro Dissolution Profile With Market Product", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp451-458, June-2019, Available at : http://www.jetir.org/papers/JETIR1908B58.pdf

Publication Details

Published Paper ID: JETIR1908B58
Registration ID: 230637
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.23408
Page No: 451-458
Country: -, -, - .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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