• Shivani Singh
• Dr. Alok Pal Jain
• Dr.Mayank Gangwar

: The aim of present paper is to evaluate the analgesic and anti-inflammatory potential of three medicinal plants by using albino rat/mice model. The all three plants i.e. Atrocarpus Heterophyllus (AHEM), Pongamia Glabra (PGEF) and Piper Nigrum (PNEP) has been selected and Soxhlet extraction process is utilized for the separation of active constituents of interest. Albino rat and mice model was employed for the determination of analgesic and anti-inflammatory potential of the plants extract. The plants extract i.e. AHEM, PGEF and PNEP has been tested for the activity having the three different concentration 100, 200 and 400 mg/kg. The result of analgesic activity by the acetic acid induced writhing in mice model, depicted that the plant extract AHEM and PENP at 400 mg/kg concentration has appears to be best effective in reducing the number of wriths by 69.11% and 64.70% respectively, in comparison to acetylsalicylic acid (63.23%). Anti-inflammatory screening by carrageenan induced paw edema rat model suggested that AHEM and PENP at 400mg/kg concentration shown 56.11% and 55.03% inhibition, in contrast to Diclofenac (54.31%). Histopathology of stomach was also performed in cotton pellet induced granuloma model to assess ulcerogenic property and depicted that diclofenac shown more ulceration and congestion in stomach as compare to plants extract. The data obtained from anti-inflammatory and analgesic model suggest that, AHEM having superior analgesic and anti-inflammatory activity than PGEF and PNEP and having potential candidate to cure the inflammation.

inflammatory, analgesic, mice model, piper nigrum, diclofenac.

"SCREENING OF SELECTED MEDICINAL PLANTS FOR ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.579-592, June 2019, Available :http://www.jetir.org/papers/JETIR1908B74.pdf

"SCREENING OF SELECTED MEDICINAL PLANTS FOR ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp579-592, June 2019, Available at : http://www.jetir.org/papers/JETIR1908B74.pdf