• A Bharath kumar
• Dr. Pabba Parameshwar

The objective of this present investigation was to study the effect of different matrix based extended release tablets of Quetiapine fumarate (QF). Different batches of Quetiapine fumarate Extended release tablets were prepared by granulation and followed by coating technique using different polymers and to elucidate the dissolution release pattern of drug from ER matrix tablets, and compare with the theoretical extended release profile of Serquoel (Quetiapine Fumarate ) tablets. And the different polymers used are Hydroxypropylmethylcellulose different grades (Methocel K4 CR, K15M, K100M, K100LV and HPMC E6 for polymer coating) were used as polymers and by comparing the combination of different polymers was found to provided better-controlled release characteristics with excellent drug release. The prepared tablets were evaluated for Physical parameters (weight variation, friability, hardness, thickness) and in vitro dissolution studies. From the In vitro dissolution studies it is clear that as the concentration of polymer increased, drug release was found to be retarded and which was compared with innovator (Serquoel XL Tablets 400mg). Formulation F1and F6 gave better-controlled drug release in comparison to the other formulations.

Hydroxypropylmethylcellulose (Different Grades), Extended tablets, Quetiapine fumarate, Kinetics.

"EFFECT OF HPMC ON DISSOLUTION QUETIAPINE FUMARATE EXTENDED RELEASE TABLETS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.16-24, June-2019, Available :http://www.jetir.org/papers/JETIR1908C04.pdf

"EFFECT OF HPMC ON DISSOLUTION QUETIAPINE FUMARATE EXTENDED RELEASE TABLETS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp16-24, June-2019, Available at : http://www.jetir.org/papers/JETIR1908C04.pdf