• D. Kosalai
• Dr.Muthiah Chandran

Cholelithiasis is most prevalent gastrointestinal diseases in Indian sub-continent because of consumption of Westernization diet, sedentary lifestyle and craving for fast food culture. This disease affects all peoples irrespective of gender and ages. However, the prevalence this disease is higher in the youngster age group up to 25 due to soft drink and tea consumption, low physical inactivity, high body mass index (BMI), frequent intake of junk food in the form of sweet foods and high refined sugars, low fibre contents, high fructose intake, fast food, high fat, and low vitamin C intake. Doctors follow surgical treatments such as laparoscopic cholecystectomy and open cholecystectomy, and non-surgical treatments such as endoscopy retrograde cholangiopancreatography (ERCP), oral dissolution therapy and shock wave lithotripsyto cure this gallstone disease. All these treatments are costly and have some post-operative complications. Hence, recent times most of the peoples seek alternative and traditional medication system such as Ayurveda, Yoga, Naturopathy, Unani, Siddha, Homeopathy and Acupuncture to treat various diseases without any side effects and at low cost. Among these, Siddha system of medicine is the foremost than all other medical systems in the world, in which the plants are used in various forms and through various root of delivery system to treat the diseases. Hence, in the present study, the plant Silybum marianum plant leaf extract and AuNPs of Silybum marianum are used to test the efficacy of gallstone prevention and dissolution in a cholesterol fed mice.

Gastrointestinal diseases, Silybum marianum, AuNPs, Gallstone, Cholesterol

"Antilithiasic and hypolipidaemic effect of AuNPs of Silybum marianum on lithogenic diet fed mice gallbladder", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.345-360, June-2019, Available :http://www.jetir.org/papers/JETIR1908C44.pdf

"Antilithiasic and hypolipidaemic effect of AuNPs of Silybum marianum on lithogenic diet fed mice gallbladder", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp345-360, June-2019, Available at : http://www.jetir.org/papers/JETIR1908C44.pdf