• Dr. Rinky Kumari

The titled compound were prepared from 2-acetylnaphtho [2, 1-b] furan as starting materials .The starting materials have been synthesized by literature (Stoermer and Schaffer) method. It is then converted in to a series of substituted chalcone 1a-e by Claisen -Schmidt condensation with substituted aromatic aldehydes. These chalcones on reaction with thiourea in presence of ethanol and concentrated hydrochloric acid gave their corresponding thiopyrimidine derivatives 2a-e, subsequent treatment with mono chloroacetic acid and anhydrous sodium acetate yields 5-(4-substitued aryl) -7 - (naphtho [2, 1-b] furan -2-yl) -2H – thiazole [3, 2-α ] pyrimidine -3(5H)-one derivatives 3a-e. The newly synthesized compounds are characterized by elemental analysis and spectral studies. Finally they have been evaluated for biological activity.

Naphthofuran, chalcone, chloroacetic acid, thiopyrimidine, thiazolidinone, sodium acetate.

"Synthesis of Some New Thiazolidinone Derivatives Containing Naphthofuran Moiety And Study of Their Biological Activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 11, page no.960-964, November-2019, Available :http://www.jetir.org/papers/JETIR1912129.pdf

"Synthesis of Some New Thiazolidinone Derivatives Containing Naphthofuran Moiety And Study of Their Biological Activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 11, page no. pp960-964, November-2019, Available at : http://www.jetir.org/papers/JETIR1912129.pdf