UGC Approved Journal no 63975(19)

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Published in:

Volume 6 Issue 12
December-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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JETIR1912184


Registration ID:
318479

Page Number

1386-1400

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Title

Characterization of Synthesis and Biological Studies of Some Transition Metal Complexes of New Schiff Bases of Sulfa Drugs

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Abstract

The transition metal complexes find extensive applications in technology, industry and medicine. The recognition of the potential employment of transition metal complexes and chelates in therapeutic applications provides useful outlets for basic research in transition metal chemistry. Metals play a vital role in an immersing number of extensively differing biological processes. Some of these processes are quite specific in their metal ion requirements Coordination compounds including Schiff base ligands are significantly important because they play a vital role in the life process and are well-known for their antibacterial, antifungal, anti-HIV, anti-inflammatory, analgesic, antitumor, antimalarial, anti dyslipidemic, anticonvulsant activities. The azomethine linkage (–N=CH) is a significant feature that makes Schiff base an important biological active species as well as ligands for coordination. Schiff bases have been recently focused by the coordination chemists as versatile ligands because of their preparative accessibilities and structural varieties. The interaction between transition metal ions and biologically active Schiff base ligands becomes an important route in designing new metal-based antibacterial and antifungal agents against different kinds of bacteria, fungi, and associated viruses that become resistant to the conventional drugs. Literature review suggests that sulphonamides are well known for their wide range of biological activity. Hydrazono groups is also considered a physiologically active group. Therefore it is considered worthwhile to synthesis some new Schiff base ligands by the reaction of diketones (derived from sulphonamides), with heterocyclic amines. The Ti (III), V (IV), Cr (III), and Co (III) complexes of newly synthesized Schiff bases have been synthesized with corresponding metal halides. The newly synthesized Schiff base ligands and complexes were characterized by elemental and spectral analysis. Geometries of the complexes were established on the basis of electronic spectra of complexes and magnetic susceptibility measurement. The biological activity of synthesized Schiff bases and their Ti (III), V (IV), Cr (III), and Co (III) complexes have been evaluated against selected bacteria and fungi.

Key Words

Biological, Metal Complexes, Synthesis, Schiff, Sulfa Drugs

Cite This Article

"Characterization of Synthesis and Biological Studies of Some Transition Metal Complexes of New Schiff Bases of Sulfa Drugs", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 12, page no.1386-1400, December-2019, Available :http://www.jetir.org/papers/JETIR1912184.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Characterization of Synthesis and Biological Studies of Some Transition Metal Complexes of New Schiff Bases of Sulfa Drugs", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 12, page no. pp1386-1400, December-2019, Available at : http://www.jetir.org/papers/JETIR1912184.pdf

Publication Details

Published Paper ID: JETIR1912184
Registration ID: 318479
Published In: Volume 6 | Issue 12 | Year December-2019
DOI (Digital Object Identifier):
Page No: 1386-1400
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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