• T Amru Umara

Background: Menopause is a condition of permanent cessation of menstrual cycle due to loss of ovarian activity resulting in a decrease in estrogen, as a result, metabolic changes can occur such as dyslipidemia. In addition, decreased estrogen levels have been shown to increase oxidative stress in the body. Malondialdehyde is a marker of oxidative stress and can be monitored as a developmental predictor of atherosclerosis. It is also known that menopausal women are more prone to experiencing dyslipidemia which can trigger coronary heart disease. Objective: Analyze the correlation between serum MDA levels with lipid profiles in menopausal women in Methods: This research is an observational descriptive study with a case series design in which case are nurses and midwives who have menopause naturally in Dr. Pirngadi Hospital, North Sumatra, Indonesia. Data is collected from January 2020 until the sample is fulfilled. This study used a sample of 31 people by consecutive sampling. Subjects were performed anamnesis and body mass index (BMI) measurements. Serum MDA levels and lipid profiles were examined by laboratory tests of venous blood using the ELISA (Enzyme Linked Immunosorbent Assay) method. Then data is collected and analyzed using statistical analysis. Results: In this study a positive correlation was obtained between serum MDA levels and total cholesterol levels (p = 0.024; r = 0.403), LDL (p = 0.019; r = 0.418), and triglycerides (p = 0.040; r = 0.317) in postmenopausal women. However, no significant correlation was found between serum MDA levels and HDL (p = 0.393; r = -0.159). There is a correlation between serum MDA levels with duration of menopause (p = 0.004; r = 0.499). There is a correlation between serum MDA levels with BMI (p = 0.002; r = 0.532). Conclusion: The higher the serum MDA level, the higher the total cholesterol, LDL, and triglyceride levels. However, there is no correlation between serum MDA levels and HDL levels. There is a correlation between serum MDA levels with duration of menopause and BMI

serum malondialdehyde, menopause, lipid profile , BMI

"Correlation Between Serum Malondialdehyde (MDA) Levels and Lipid Profile in Menopausal Women in Dr. Pirngadi Hospital Medan", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.1195-1202, February-2020, Available :http://www.jetir.org/papers/JETIR2002170.pdf

"Correlation Between Serum Malondialdehyde (MDA) Levels and Lipid Profile in Menopausal Women in Dr. Pirngadi Hospital Medan", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp1195-1202, February-2020, Available at : http://www.jetir.org/papers/JETIR2002170.pdf