UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
Call for Paper
Volume 11 | Issue 3 | March 2024

JETIREXPLORE- Search Thousands of research papers



WhatsApp Contact
Click Here

Published in:

Volume 7 Issue 2
February-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

7.95 impact factor calculated by Google scholar

Unique Identifier

Published Paper ID:
JETIR2002250


Registration ID:
227837

Page Number

333-338

Share This Article


Jetir RMS

Title

STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF GLASDEGIB BY RP-HPLC

Abstract

A validated stability indicating RP-HPLC method for glasdegib was developed by separating its degradation products on a C18 (150x4.6mm, 3.5µm) waters symmetry column using 1ml Tri Ethyl Amine of pH=7.0 adjusted with Ortho Phosphoric acid and acetonitrile in simple isocratic at a flow rate of 1.0 ml/min. The column effluents were monitored by a photodiode array detector set at 268nm. The method was validated in terms of specificity, linearity, accuracy, precision, detection limit, quantification limit and robustness. Forced degradation of Glasdegib was carried out under acidic, basic, peroxide, reduction, thermal, photo and hydrolysis conditions. The proposed method is validated as per ICH Q2 (R1) guidelines.

Key Words

Glasdegib, Method Validation, RP-HPLC

Cite This Article

"STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF GLASDEGIB BY RP-HPLC", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.333-338, February-2020, Available :http://www.jetir.org/papers/JETIR2002250.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF GLASDEGIB BY RP-HPLC", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp333-338, February-2020, Available at : http://www.jetir.org/papers/JETIR2002250.pdf

Publication Details

Published Paper ID: JETIR2002250
Registration ID: 227837
Published In: Volume 7 | Issue 2 | Year February-2020
DOI (Digital Object Identifier):
Page No: 333-338
Country: Vijayawada/Krishna, AP, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


Preview This Article


Downlaod

Click here for Article Preview

Download PDF

Downloads

0003055

Print This Page

Current Call For Paper

Jetir RMS