• Smita Akshay Chavan
• Aparna Ajinkya Swami

The present research work focuses on the use of mesoporous substance like Syloid 244 FP (amphorous silicon dioxide) and Montmorillonite in the drug delivery system as a drug carrier. Solid dosage form (pellet) was formulated by using extrusion-spheronisation technique. The syloid 244 FP have good entrapment capacity of drug as compare to the montmorillonite. The Syloid 244 FP doesn’t shows any change in drug content even after change in its proportion with drug. In comparison to that MMT changes in drug content with change in its proportion with drug. For MMT pellets with increase in concentration of MMT increase the hardness of pellets. SEM confirms the smooth and regular surface of MMT pellets as compare to rough and irregular surface of Syloid 244 FP. In comparison to GR product the optimized pellets containing (drug-mesoporous material-polymer composite) showed same acid protection for initial 2 hours. Following that the release was found to gradual upto 5 hours. The marketed Sustained release tablet also shows sufficient acid protectionof drug in initial 2hrs, followed by sustained release up to 12-24 hours. While optimized pellets of mesoporous material (MMT and Syloid 244 FP) the initial acid protection upto 2 hours and then sustained release upto 6 hours. The Stability studies of optimized formulations did not show any significant change in drug content when kept at accelerated stability condition and there was no significant difference in values of % drug content as well as % drug release after 6 hours observed during the stability studies conducted upto 90 days. The mean paw edema volume shows the inflammation was sufficiently decreased in test group as compare to control group and standard group. Optimized formulation shows significant (P< 0.001) reduction in inflammation upto 4 hours. The optimized test formulation of Syloid 244 FP shows the higher percent reduction of edema in rats paw upto 4hours as compared to the mmt formulation which shows maximum reduction upto 3 hours.

Dicolfenac Sodium (DS), Montmorillonite, Syloid 244fp, Gastro retentive (GR)

"Formulation and Evaluation of Mesoroporous Carriers for Oral Drug Delivery System", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.911-924, February-2020, Available :http://www.jetir.org/papers/JETIR2002344.pdf

"Formulation and Evaluation of Mesoroporous Carriers for Oral Drug Delivery System", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp911-924, February-2020, Available at : http://www.jetir.org/papers/JETIR2002344.pdf