UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 7 Issue 2
February-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2002355


Registration ID:
228458

Page Number

987-1004

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Title

An Acute toxicity profile of Tramadol on Rattus norvegicus – A case study of up and down regulations and Psychobiotic clinical approach

Abstract

In recent years, many opioids are enter into the human life, among them one of the widely used popular opioid, that is extremely recommended for effective analgesic agent to treat more severe acute and chronic pains are named as Tramadol hydrochloride. On using the long-term and higher doses of Tramadol induce seizures might be Serotonin syndrome and acute renal failure etc. The aim of the present study is to investigate the acute lethal dose (LD50) of the Tramadol through oral administration in Rattus norvegicus by Dixon’s Up and Down LD50 method. This method improves the performances and accurate results for estimating the toxicity and also the notable on reduction of test animals for using the LD50 determination. The current study shows the significance of Psychobiotic that could reduce the toxicity of opioid effects. Lactobacillus helveticus - MCC 2036 was shown astonishing mark on reduces lethal toxic effects of tramadol while comparing lethal and control groups. The present investigation, Oral administration of Tramadol LD50 dose along with Psychobiotic therapy were compared with control group at weekly intervals of short and long period effects, assess by the changes on behavioral characters with their mortality signs of each animal, Biochemical profiles and Histological modifications on brain, liver and kidney tissues.

Key Words

Tramadol, Rattus norvegicus , Psychobiotic therapy, Up and Down LD50 estimation, Biochemical analysis and Histological studies.

Cite This Article

"An Acute toxicity profile of Tramadol on Rattus norvegicus – A case study of up and down regulations and Psychobiotic clinical approach", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.987-1004, February-2020, Available :http://www.jetir.org/papers/JETIR2002355.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"An Acute toxicity profile of Tramadol on Rattus norvegicus – A case study of up and down regulations and Psychobiotic clinical approach", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp987-1004, February-2020, Available at : http://www.jetir.org/papers/JETIR2002355.pdf

Publication Details

Published Paper ID: JETIR2002355
Registration ID: 228458
Published In: Volume 7 | Issue 2 | Year February-2020
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.23151
Page No: 987-1004
Country: Tirupati, Andhra Pradesh, India .
Area: Biological Science
ISSN Number: 2349-5162
Publisher: IJ Publication


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