• Dr Isha Malik
• Dr Ashuma Sachdeva
• Dr Vandana Rani
• Dr Monica Verma

Abstract : Pregnancy is a hypermetabolic state with major physiological alterations affecting all the systems of the body. A healthy woman undergoes many physiological adaptations just for the normal pregnancy. At the neuroendocrinal as well as at the placental level hormonal interaction is mainly responsible for the normal reproductive function. Thus recurrent and early pregnancy loss may be associated with a variety of imbalances and genetic anomalies. The elevated levels of prolactin interfere with the action of gonadotrophins at the ovarian level. Abnormal thyroid functions also cause ovulatory dysfunction and recurrent abortions. So, this study was planned to estimate and compare the levels of Prolactin and TSH in pregnancy with bad obstetrical history and normal pregnant women. A total of 100 females were included out of which 50 were normal pregnant females as controls and 50 pregnant females having history of recurrent abortions as study group attending the Obstetrics and Gynaecology OPD at PGIMS Rohtak . The serum levels of Prolactin and TSH were estimated by chemiluminescent immunoassay on Advia Centaur CP and mean and SD of all the parameters was compared in the groups. Also anti TPO antibody was measured in both the groups on Immulite 1000. Prolactin and TSH levels were found to be significantly elevated in the study group as compared to controls. Four patients also showed an elevated levels of anti TPO antibody. Our findings support the fact that increased TSH and prolactin levels were found in cases having history of abortions and still birth. We conclude that any type of change in the endocrine functions in may affect the pregnancy outcome. I

ndexTerms – Prolactin, TSH, Abortion, Anti TPO antibody.

"COMPARISON OF LEVELS OF PROLACTIN AND TSH IN PREGNANCY WITH BAD OBSTETRICAL HISTORY AND NORMAL PREGNANT WOMAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 3, page no.198-202, March-2020, Available :http://www.jetir.org/papers/JETIR2003331.pdf

"COMPARISON OF LEVELS OF PROLACTIN AND TSH IN PREGNANCY WITH BAD OBSTETRICAL HISTORY AND NORMAL PREGNANT WOMAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp198-202, March-2020, Available at : http://www.jetir.org/papers/JETIR2003331.pdf