• Dr Naveen Kumar Podila
• Pendem Omprakash

The new derivatives of 2,3,6,7-tetra substituted-N-(3-chloroquinoxalin-2-yl)acridin-9-amine (6a-l) have been synthesized, and most of the derivatives were promisingly active towards anti bacterial, anti cancer strains as compared with ampicilin as positive controls due to the presence of quinoxaline and acridine heterocyclic reaction systems. All the new derivatives were prepared from 2-chloro-4,5-disubstituted benzoic acid (2a-l) condensed with 3,4-disubstited aniline (1a-l) in the presence of potassium carbonate, copper powder in isopropyl alcohol yields 2-((3,4-di substituted phenyl)amino)-4,5-disubstituted benzoic acid (3a-l). Reacting 3a-l with phosphorus oxy chloride, ammonium carbonate in the presence of phenol yields 2,3,6,7-tetra substituted acridin-9-amine (4a-l). Finally 2,3-dichloroquinoxaline (5) reacts with 2,3,6,7-tetra substituted acridin-9-amine (4a-l) to form N-(3-chloroquinoxalin-2-yl)-2,3,6,7-tetra substituted acridin-9-amines (6a-l). The structures of the resulted compounds (6a-l) were identified and confirmed by IR, 1H-NMR, Mass spectral data and elemental analysis. All the synthesized derivatives were screened for their antimicrobial and anticancer activity.

2-chloro-4,5-disubstituted benzoic acid(2a-l), 3,4-disubstituted aniline(1a-l), 2,3-dichloro quinoxaline(5), N-(3-chloroquinoxalin-2-yl)-2.3,6,7-tetra substituted acridine-9-amines (6a-l), anti bacterial activity, anti cancer activity

"Synthesis of New derivatives of 2,3,6,7-tetra substituted –N-(3-chloroquinoxalin-2-yl)acridin-9-amine and their anti bacterial, anti cancer activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 4, page no.273-280, April-2020, Available :http://www.jetir.org/papers/JETIR2004039.pdf

"Synthesis of New derivatives of 2,3,6,7-tetra substituted –N-(3-chloroquinoxalin-2-yl)acridin-9-amine and their anti bacterial, anti cancer activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 4, page no. pp273-280, April-2020, Available at : http://www.jetir.org/papers/JETIR2004039.pdf