• Pooja Soni
• Zaineb Qureshi
• Misha Masood
• Dr. Surendra Jain

With an aim to study wound healing activity of Dalbergia sissoo leaves in alloxan induced hyperglycemic rats, wounds were created after the induction of diabetes with alloxan (125 mg/kg) in albino wistar rats by intraperitoneal administration. Rats were topically treated with Dalbergia sissoo leaves extract which was formulated in the form of ointment and wound healing activity of Dalbergia sissoo leaves (5% and 10% w/w, topically) was observed. Antioxidants have been reported to play a significant role in improving the wound healing process and protecting the tissues from oxidative damage. As a result, antioxidants were detected for their presence in the extracts using ascorbic acid as standard through superoxide scavenging assay and reducing power assay. Wound which were treated with ointment contining 5% and 10% extract of Dalbergia sissoo leaves showed significant wound healing effect. Wound contraction in upto 20th days was 29.33+/-3.055 mm in control group while the contraction in group 4 (diabetic rats with wound, given extract 5% ointment) and 5 (diabetic rats with wound, given extraxct 10 % ointment) was 41.00+/-3.606 and 26.67+-1.528 respectivly. The extract of Dalbergia sissoo leaves had properties that render it capable of promoting accelerated wound healing activity compared with the controls. On the basis of the results obtained in the present study, it is possible to conclude that Dalbergia sissoo leaves ointment has significant wound healing activity in rats with diabetes.

Dalbergia Sisso, Wound, Diabetes, Alloxan

"Evaluation of wound healing activity of dalbergia sisso leaves in alloxan induced hyperglycemic rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 4, page no.368-382, April-2020, Available :http://www.jetir.org/papers/JETIR2004054.pdf

"Evaluation of wound healing activity of dalbergia sisso leaves in alloxan induced hyperglycemic rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 4, page no. pp368-382, April-2020, Available at : http://www.jetir.org/papers/JETIR2004054.pdf