• GOLHAR AARTI RAJENDRA*
• VAISHALI K.GHUME
• DR. ABHIJIT N. MEREKAR
• PROF.MAHESH D.DOKHE
• Dipshri B. Patil

Liposome is the most common and well-investigated nano carriers for targeted drug delivery. They have improved therapies for a range of biomedical applications by stabilizing therapeutic compounds. . Liposome is defined as phospholipids vesicles consisting of one or more concentric lipid bilayers enclosing discrete aqueous spaces. Topical drug delivery is an attractive route for local and systemic treatment. Linezolid is a synthetic antibiotic, an oxazolidinone derivative that is active against bacteria. Linezolid is available commercially as tablets and injections only in spite of its well known adverse effects including nausea, vomiting, headache, diarrhea and abdominal discomfort. Oral Linezolid infectious diseases caused mainly by aerobic gram positive bacteria, certain negative bacteria and anaerobic cannot be taken in conjugation with a number of medications. They are capable of incorporate a variety of hydrophilic and hydrophobic drugs to enhance the accumulation of drug at the administration site and to reduce side effects. The objective of the present study was to develop a Linezolid loaded liposomal gel for better anti-bacterial activity by sustaining the drug release and reduces adverse effects. Linezolid is a synthetic antibacterial agent of a new class of Oxazolidinone, which has more effective clinical utility in treatment of infectious diseases compared to Vancomycin, Methicillin.Linezolid liposome were prepared by thin film hydration technique using soya lecithin, Stearic acid, cholesterol and drug in different weight ratios. They were evaluated for particle size, entrapment efficiency and in vitro drug release.

liposomal drug delivery, nano carriers, in vivo, in vitro.

"FORMULATION AND EVALUATION OF LIPOSOMAL TOPICAL GEL OF LINEZOLID FOR THE TREATMENT OF SKIN INFECTION”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 4, page no.1105-1134, April-2020, Available :http://www.jetir.org/papers/JETIR2004151.pdf

"FORMULATION AND EVALUATION OF LIPOSOMAL TOPICAL GEL OF LINEZOLID FOR THE TREATMENT OF SKIN INFECTION”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 4, page no. pp1105-1134, April-2020, Available at : http://www.jetir.org/papers/JETIR2004151.pdf