• Abhijit Popat Ahirrao
• Pankaj Kailas Deshmukh
• Dr.Vishal Pande

Roller compaction is a dry granulation process device procedure in which the powders containing active ingredients and excipients are agglomerated between the compactor rollers. The dry powders of the active ingredients and excipients are combined in a blender during roller compaction, and further rollers are compacted and milled to form granulesThe resulting granules are then blended within in a blender and used for compression into tablets or for capsule filling. Compaction of powder is the term used to describe the situation in which these materials are subjected to some level of mechanical force. In pharmaceutical industries, the effects of such forces are very important in manufacturing of granule and tableting Particulate matter is compressed and densified in a roller compactor by rotating the material between two high pressure rollers. From a roller compactor, the densified material is then reduced by Frying to a uniform granule size. Roll compaction / dry granulation is a method of choice for the treatment of drugs sensitive to physical or chemical moisture, as no liquid binder is required in th. This analysis of the literature shows the development and use of RCDG in directly compressible excipient processing, drug compaction, and drug formulations. Avoiding deterioration caused by wet granulation, improving product quality, preventing segregation, reducing bulk volume, thereby decreasing storage volume and thus increasing transport efficiency and reducing possible environmental hazards. Dis-advantages of roller compaction are densification of the powder or particle which can adversely affects the dissolution of product and the powder to be compacted must be compressible or have to add compressible excipients or additives to the formulation. Sophistications available with roller compaction system are roller cooling or heating, vacuum de aeration.

Tablets, granulation, roll compaction, direct compression, wet granulation

"A Review: Roller Compaction for Tablet Dosage Form Development ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 4, page no.1738-1747, April-2020, Available :http://www.jetir.org/papers/JETIR2004435.pdf

"A Review: Roller Compaction for Tablet Dosage Form Development ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 4, page no. pp1738-1747, April-2020, Available at : http://www.jetir.org/papers/JETIR2004435.pdf