• Prof RS Chauhan
• TULSA DEVI

The antibiotics, 20th century wonder drug, were first developed in 1935 and thereafter, many antibiotics came in the market to treat, prevent and control the bacterial diseases. However, with the passage of time and following natural law of survival of the fittest, many bacteria developed resistance against these antibiotics and situation became so worrisome that at present many superbugs are present in the environment on which presently available antibiotic drugs are not having any effect. The antibiotic resistance to microbes leads to severe consequences. Infections caused by resistant microbes fail to respond to treatment resulting in prolonged illness and greater risk of death, longer periods of hospitalization and infections which increases the number of infected people moving in the community. When an infection becomes resistant to first line antibiotic, treatment has to be switched to second or third line drugs, which are always much more expensive and sometime more toxic as well. In poor countries, where many of the second or third line therapies for drug resistant infections are not available, making the potential of resistance to first line antibiotics considerably greater. The limited number of antibiotics in these countries are becoming increasingly inadequate for treating infections and necessary antibiotics to deal with infections caused by resistant pathogens are absent from essential drug list. Medicinal plants are a source of great economic value all over the world. Nature has bestowed on us a very rich botanical wealth and a large number of diverse types of plants grow in different parts of the country. The beneficial medicinal effects of plant materials typically result from the combinations of secondary products present in the plant. In plants, these compounds are mostly secondary metabolites such as alkaloids, steroids, tannins, and phenol compounds, flavonoids , steroids, resins fatty acids gums which are capable of producing definite physiological action on body. Compounds extracted from different parts of the plants can be used to cure diarrhoea, dysentery, cough, cold, cholera, fever bronchitis etc. This study was planned for the in vitro assessment of various extracts of Aloe barbadensis plant leaves for their antibacterial activity. Extracts of the Aloe barbadensis were prepared in water, ethanol, methanol etc. It has been observed that these extracts showed very promising results as indicated by the zone of inhibition of bacterial culture through agar well diffusion method that varies from few mm to few cm. The bacteria used in this study were common pathogen of human and animals and were resistant to the commonly available antibiotic drugs. This study indicates the in-vitro antibacterial effects of Aloe barbadensis extracts which further needs confirmation and validation of its antibacterial effect both in in-vitro and in-vivo.

Key words: Aloe barbadensis, Leaf extracts, Antibacterial sensitivity, Agar gel diffusion test.

"Assessment of in vitro antibacterial activity of Aloe barbadensis leaf extracts", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 4, page no.284-291, April 2020, Available :http://www.jetir.org/papers/JETIR2004532.pdf

"Assessment of in vitro antibacterial activity of Aloe barbadensis leaf extracts", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 4, page no. pp284-291, April 2020, Available at : http://www.jetir.org/papers/JETIR2004532.pdf