UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 7 Issue 6
June-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2006222


Registration ID:
234199

Page Number

1503-1514

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Title

ASSAY METHOD AND VALIDATION FOR THE CARVEDIDOLTABLET FORMULATION BY USING RP-HPLC.

Abstract

A simple, efficient, and precise stability indicating RP-HPLC method has been developed and validated to measure Carvedilol at wavelength (242 nm) in order to assay. Carvedilol is used to treat chronic heart failure. Methanol was used as a solvent with λmax of drug was found to be 242 nm. The samples were eluted in an isocratic method using YMC pack pro c18(100×4.6mm,5µ) column at ambient temperature,for 8min run time with 1.0ml/min flow rate was used with a mobile phase consisting of pH 3.0 Buffer Dipotassium Hydrogen Phosphate: ACN (60:40) using as diluents through ambient temperature delivered at a flow rate 1.0mL/min. Linearity was observed in the range of 25-150% with a regression coefficient of 0.99. The method was quantitatively evaluated in terms of accuracy (recovery), linearity, in accordance with standard ICH validation guidelines. The method is simple and suitable for analyzing Carvedilol in bulk and in pharmaceutical formulations.

Key Words

RP-HPLC, carvdilol,wavelength ,ICH validation guideline.

Cite This Article

"ASSAY METHOD AND VALIDATION FOR THE CARVEDIDOLTABLET FORMULATION BY USING RP-HPLC.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 6, page no.1503-1514, June-2020, Available :http://www.jetir.org/papers/JETIR2006222.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"ASSAY METHOD AND VALIDATION FOR THE CARVEDIDOLTABLET FORMULATION BY USING RP-HPLC.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp1503-1514, June-2020, Available at : http://www.jetir.org/papers/JETIR2006222.pdf

Publication Details

Published Paper ID: JETIR2006222
Registration ID: 234199
Published In: Volume 7 | Issue 6 | Year June-2020
DOI (Digital Object Identifier):
Page No: 1503-1514
Country: -, -, - .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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