UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2006284


Registration ID:
234401

Page Number

1961-1972

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Title

Preparation and evaluation of buccoadhesive gel containing optimized Febuxostat-loaded microemulsion

Abstract

The purpose of this study is to develop and characterize a successful colloidal nano-carrier viz. microemulsion for oral delivery as well as for topical delivery of antigout drug. Gout is a metabolic disorder which causes inflammation of the joints hence the pain. It is the most common crystal arthropathy and induced by the deposition of monosodium urate (MSU) crystal in joint and soft tissues that can produce an acute or chronic arthritis or inflammatory arthritis. The present study will conduct to investigate the microemulsion based drug delivery system of antigout drug febuxostat( FBT) in order to bypass its gastrointestinal adverse effect and to improve patient compliance and hence improve therapeutic efficacy.. Microemulsion will develop and optimize using box behnken design i.e. by using design expert software. The develop microemulsion based gels will characterized for pH, spreadability , drug content, viscosity and transdermal permeability of drug. Optimized gel formulation will then subject to in vitro antigout study in comparison to marketed available formulation of Febuxostat by using monosodium urate (MSU) crystals induced animal model.

Key Words

Keywords:Febuxostat, microemulsion, microemulsion based gel, antigout, transdermal permeability and topical delivery

Cite This Article

"Preparation and evaluation of buccoadhesive gel containing optimized Febuxostat-loaded microemulsion", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.1961-1972, June-2019, Available :http://www.jetir.org/papers/JETIR2006284.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Preparation and evaluation of buccoadhesive gel containing optimized Febuxostat-loaded microemulsion", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp1961-1972, June-2019, Available at : http://www.jetir.org/papers/JETIR2006284.pdf

Publication Details

Published Paper ID: JETIR2006284
Registration ID: 234401
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier):
Page No: 1961-1972
Country: Bijnor, Uttar Pradesh, India .
Area: Pharmacy
ISSN Number: 2349-5162


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