• Kalyani Sharma
• Dr. Dinesh Sharma

Pulsatile drug delivery is an interesting area which is gaining attention as it offers more sophisticated and better approach over the traditional sustained release and conventional drug delivery systems. The main advantages are improved dosage regimen, reduced first pass metabolism, reduced dose dumping and side effects and, better bioavailability of medicine. A well structured pulsatile system would control the fluctuations in plasma drug level by facilitating the preprogrammed drug release with a definite predetermined lag time to mimic the circadian rhythm of the disease. A pulse is designed in such a way so as to achieve a complete and rapid drug release after the lag time which matches the circadian rhythm of body that increases the efficacy and safety of drugs by adjusting their peak plasma concentrations in synchronization with biological rhythm. This review gives an overview of various approaches employed to develop pulsatile drug delivery system.

Pulsatile, polymers, circadian rhythm, bioavailability, preprogrammed, lag time

"A REVIEW ON PULSATILE DRUG DELIVERY SYSTEM AND VARIOUS APPROACHES USED TO DESIGN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 6, page no.1096-1103, June-2020, Available :http://www.jetir.org/papers/JETIR2006494.pdf

"A REVIEW ON PULSATILE DRUG DELIVERY SYSTEM AND VARIOUS APPROACHES USED TO DESIGN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp1096-1103, June-2020, Available at : http://www.jetir.org/papers/JETIR2006494.pdf