UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 7 Issue 6
June-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2006573


Registration ID:
234874

Page Number

1695-1704

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Title

Rp-Hplc Assay Method For Estimation Of Dimethyl Fumarate In Bulk And Capsules

Abstract

A simple, sensitive and accurate gradient reverse phase high performance liquid chromatography method was developed for determination of dimethyl fumarate in formulation . RP-HPLC method has been developed and validated to live dimethyl fumarate at wavelength ( 210nm)in order to assay. The retention time of dimethyl fumarate was found to be 3.3±0.02 min. the worth of coefficient of correlation between peak area and concentration was found to be 0.9987. The mean percent recovery of dimethyl fumarate in capsules was found within the range of 99.65 to 101.64%. The results of forced degradation studies indicated that the drug was found to be stable in basic, oxidative and thermal conditions while degraded in acidic conditions.The mixture of buffer and ACN ,in the ratio (70:30) used as a mobile phase .It are often conducted from results that the developed HPLC method is straightforward , accurate, precise and specific. Results of stress testing study revealed that the tactic is stability indicating. Thus, this method are often used for routine analysis of dimethyl fumarate capsules and check their stability.

Key Words

RP-HPLC, Method validation, Stability indicating assay method, Dimethyl fumarate, Simple and accurate method.

Cite This Article

"Rp-Hplc Assay Method For Estimation Of Dimethyl Fumarate In Bulk And Capsules", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 6, page no.1695-1704, June 2020, Available :http://www.jetir.org/papers/JETIR2006573.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Rp-Hplc Assay Method For Estimation Of Dimethyl Fumarate In Bulk And Capsules", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp1695-1704, June 2020, Available at : http://www.jetir.org/papers/JETIR2006573.pdf

Publication Details

Published Paper ID: JETIR2006573
Registration ID: 234874
Published In: Volume 7 | Issue 6 | Year June-2020
DOI (Digital Object Identifier):
Page No: 1695-1704
Country: pune, Maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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