• Ananta B. Ghonge
• Manish R. Bhise
• Shubham P. Kokate
• Pramod V. Burakle
• Vishal B. Patond

: Mosapride citrate is a 5-HT4 agonist and its action must be targeted to the esophagus and the upper part of the stomach. The present work relates to development of multiparticulate floating drug delivery system based on gas generation technique to prolong the gastric residence time and to increase the overall bioavailability. Modified release dosage form of mosapride citrate adapted to release over a predetermined time period, according to biphasic profile of dissolution. The system consists of mosapride citrate layered pellets coated with effervescent layer and polymeric membrane. The floating ability and in vitro drug release of the system were dependent on amount of the effervescent agent (sodium bicarbonate) layered onto the drug layered pellets and coating level of the polymeric membrane (Eudragit® NE 30D). The system could float completely within 5 min and maintain the floating over a period of 12 h. The multiparticulate floating delivery system of mosapride citrate with rapid floating and modified drug release was obtained.

Gastro retentive drug delivery system; swelling index; hydro dynamically balanced tablet

"Design and in vitro evaluation of multiparticulate floating drug delivery system of Gastroprokinetic drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 8, page no.1016-1024, August-2020, Available :http://www.jetir.org/papers/JETIR2008131.pdf

"Design and in vitro evaluation of multiparticulate floating drug delivery system of Gastroprokinetic drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 8, page no. pp1016-1024, August-2020, Available at : http://www.jetir.org/papers/JETIR2008131.pdf