• MAZHAR MEHDI
• AGA MANSOOR
• S. JAMAL HAIDER ZAIDI

The hypoglycemic potential of ethanolic extract of hole plant of Andrographis paniculata was evaluated by normoglycemic rats. The plant extract was subjected to the study of presence of different phytoconstituents. Now a day, Diabetes mellitus has become a real problem of public health in developing countries. This is a metabolic disorder characterized by disarrangements in carbohydrate, protein and fat metabolism caused by the complete or relative insufficiency of insulin secretion and /or action. This is due to defective or deficient insulin secretary response. This results into impaired glucose use, which is a characteristic feature of diabetes mellitus i.e. resultant hyperglycemia. Elevated blood glucose level causes dehydration of the tissue cells as glucose does not diffuse easily through the pores of cell membrane and increased osmotic pressure. Present investigation is therefore designed to determine the effect of crude ethanolic extract of Andrographis paniculata on blood sugar of albino rat after daily oral administration of dose at the level of 250mg/kg b. wt. for five and seven days respectively. It was noticed that the chronic administration for longer duration leads to significant decrease in blood sugar compared to control. Thus it can be concluded that Andrographis paniculata also has the anti- diabetic property.

Andrographis paniculata, Albino rats, Blood sugar, Hyperglycemia, Antidiabetic property.

"Protective Role of Andrographis paniculata on the Blood Sugar of Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 8, page no.1027-1031, August-2020, Available :http://www.jetir.org/papers/JETIR2008438.pdf

"Protective Role of Andrographis paniculata on the Blood Sugar of Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 8, page no. pp1027-1031, August-2020, Available at : http://www.jetir.org/papers/JETIR2008438.pdf