UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Volume 7 Issue 10
October-2020
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2010304


Registration ID:
301357

Page Number

2343-2359

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Title

Devlopment And Validation of stability indicateing method for raltegravir potassium.

Abstract

ABSTRACT Raltegravir potassium is an antiretroviral drug. A simple and rapid stability indicating HPLC method of Raltegravir potassium was successfully developed. This method is based on HPLC separation followed by UV detection at 315 nm. HPLC method was developed on a symmetry HiQsil C18 (150 x 4.6mm id 5 μm) column with a mobile phase consisting of Methanol: Phosphate buffer: Acetonitrile 40:30:30 % v/v/v, pumped at 1.0 ml min-1 flow rate. The pH of buffer was adjusted to 3.0 with ortho phosphoric acid. The column was maintained at ambient temperature and 20μl of solutions were injected. The eluted compounds were detected by using PDA detector. Raltegravir potassium eluted at 3.3 ± 0.2 min. Stress degradation study shows that sample degraded with acid and base hydrolysis, under oxidation, thermal and photolytic stress conditions.

Key Words

KEYWORDS Raltegravir potassium, Stability indicating RP-HPLC, Forced degradation, Validation.

Cite This Article

"Devlopment And Validation of stability indicateing method for raltegravir potassium.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 10, page no.2343-2359, October-2020, Available :http://www.jetir.org/papers/JETIR2010304.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Devlopment And Validation of stability indicateing method for raltegravir potassium.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 10, page no. pp2343-2359, October-2020, Available at : http://www.jetir.org/papers/JETIR2010304.pdf

Publication Details

Published Paper ID: JETIR2010304
Registration ID: 301357
Published In: Volume 7 | Issue 10 | Year October-2020
DOI (Digital Object Identifier):
Page No: 2343-2359
Country: Jalna, Maharastra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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