• Rupesh R. Baride
• Dr. Narendra Gowekar

ABSTRACT Raltegravir potassium is an antiretroviral drug. A simple and rapid stability indicating HPLC method of Raltegravir potassium was successfully developed. This method is based on HPLC separation followed by UV detection at 315 nm. HPLC method was developed on a symmetry HiQsil C18 (150 x 4.6mm id 5 μm) column with a mobile phase consisting of Methanol: Phosphate buffer: Acetonitrile 40:30:30 % v/v/v, pumped at 1.0 ml min-1 flow rate. The pH of buffer was adjusted to 3.0 with ortho phosphoric acid. The column was maintained at ambient temperature and 20μl of solutions were injected. The eluted compounds were detected by using PDA detector. Raltegravir potassium eluted at 3.3 ± 0.2 min. Stress degradation study shows that sample degraded with acid and base hydrolysis, under oxidation, thermal and photolytic stress conditions.

KEYWORDS Raltegravir potassium, Stability indicating RP-HPLC, Forced degradation, Validation.

"Devlopment And Validation of stability indicateing method for raltegravir potassium.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 10, page no.2343-2359, October-2020, Available :http://www.jetir.org/papers/JETIR2010304.pdf

"Devlopment And Validation of stability indicateing method for raltegravir potassium.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 10, page no. pp2343-2359, October-2020, Available at : http://www.jetir.org/papers/JETIR2010304.pdf